Traumatic brain injury and the gastrointestinal tract: the role of female sexual hormones

Z Keshavarzi, AR Afshari, N Mohammadzadeh… - … of Endocrinology and …, 2018 - jofem.org
action of estrogen on the levels of intestinal cytokines [74]. Research analyzing post-TBI
intestines and serum … , especially TNF-α, which is probably mediated through estrogen receptor […

Possible involvement of female sex steroid hormones in intracellular signal transduction mediated by cytokines following traumatic brain injury

F Farahani, M Khaksari, S Amiresmaili, M Iranpour… - Brain research …, 2022 - Elsevier
… Summarily, ovariectomized (OVX) was done by using an intra-abdominal … the role of classical
and non-classical estrogen receptors in different brain cells, especially in microglia after TBI…

Shaping microglial phenotypes through estrogen receptors: relevance to sex-specific neuroinflammatory responses to brain injury and disease

M Acosta-Martínez - Journal of Pharmacology and Experimental …, 2020 - ASPET
hormone levels in young and old animals affect ER subtype … Recent studies suggest that
perturbation of the gutcytokine production play a major role in ER-mediated effects. E 2 -…

Evolution of TLR4 role in mediating the hepatoprotective effects of estradiol after traumatic brain injury in male rats

S Amiresmaili, M Khaksari, N Shahrokhi… - Biochemical …, 2020 - Elsevier
… the liver [2] and digestive tract [3]. The systemic production of … possible role of non-classical
and classical estradiol receptors … Briefly, 125 μl of serum was mixed in a test tube with 1.5 ml …

Stroke and neuroinflamation: role of sexual hormones

M Jose Perez-Alvarez… - Current pharmaceutical …, 2016 - ingentaconnect.com
… G protein (Gs), the other mPRs activate an inhibitory G protein (Gi), resulting in activation
of … estrogen receptor that is regulated during development and after ischemic brain injury. J …

[HTML][HTML] Traumatic brain injury in women across lifespan

MO Blaya, AP Raval, HM Bramlett - Neurobiology of disease, 2022 - Elsevier
… -induced systemic effects (lung/brain, gut/brain, etc.) remain … by estrogens through estrogen
receptors at acute time points … in the hippocampus, serum, and female reproductive organs of …

The role and use of estrogens following trauma

M Weniger, MK Angele, IH Chaudry - Shock, 2016 - journals.lww.com
… Especially estrogens and estrogen receptor (ER) agonists … -hemorrhage (NCT00973102)
and traumatic brain injury (TBI) (… This effect of ET I on the intestine is reported to be reversed …

[HTML][HTML] Sex as a biological variable in preclinical modeling of blast-related traumatic brain injury

JT McCabe, LB Tucker - Frontiers in neurology, 2020 - frontiersin.org
… articles to explore the role of the two estrogen receptors (ERs), … Serum levels of ACTH
have been shown to decrease 1 … , throughout the gastrointestinal tract, lungs, and brain that …

Differential Effects of Brain Death on Rat Microcirculation and Intestinal Inflammation: Female Versus Male

SG Ferreira, R Armstrong-Jr, GK Kudo… - Inflammation, 2018 - Springer
… that female rats submitted to BD also present increased serum … systemic release of cytokines
did not differ from other groups. … Estrogen receptor subtypes mediate distinct microvascular …

Impact of menopause-associated frailty on traumatic brain injury

SB Sinder, SV Sharma, IS Shirvaikar… - Neurochemistry …, 2024 - Elsevier
… of hormonal changes that extend far beyond reproductive … between serum sclerostin levels
and the free estradiol index in … large effects on gastrointestinal (GI) function, the gut-brain axis …